The connection between poor sleep, memory loss and brain deterioration as we grow older has been elusive. But for the first time, scientists at the University of California, Berkeley, have found a link between these hallmark maladies of old age. Their discovery opens the door to boosting the quality of sleep in elderly people to improve memory.
Postdoctoral fellow, Bryce Mander, demonstrates how the sleep study was conducted.
UC Berkeley neuroscientists have found that the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus — which provides short-term storage for memories — to the prefrontal cortex’s longer term “hard drive.”
However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep ‘slow wave’ sleep, and are then overwritten by new memories, the findings suggest.
“What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older — and with that, a potentially new treatment avenue,” said UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley and senior author of the study to be published Jan. 27, in the journal Nature Neuroscience.
The findings shed new light on some of the forgetfulness common to the elderly that includes difficulty remembering people’s names.
“When we are young, we have deep sleep that helps the brain store and retain new facts and information,” Walker said. “But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night.”
Healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain’s middle frontal lobe. Deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep, the study found.
The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.
UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. “Can you jumpstart slow wave sleep and help people remember their lives and memories better? It’s an exciting possibility,” said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.
For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night’s sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.
As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.
In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired “slow wave activity” during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.
Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.
The research was funded by the National Institute of Aging of the National Institutes of Health.
Could the chemicals found in marijuana prevent and even heal several deadly cancers?
Could the tumor-regulating properties of “cannabinoids” someday replace the debilitating drugs, chemotherapy, and radiation that harms as often as it heals?
Discover the truth about this ancient medicine as world-renowned scientists in the field of cannabinoid research illustrate their truly mind-blowing discoveries in this feature-length documentary.
Using original and archival footage, the film presents controversial but highly convincing evidence that this forbidden herb has healing properties beyond any other plant on the planet— interacting as it does with the body’s own “endocannabinoid system” to keep us fit and disease-free.
“What if Cannabis Cured Cancer” explains how we are all born with a form of marijuana already in our bodies, and when pot is consumed, the “endocannabinoids” inside us—along with any cannabinoids we ingest—fit together like a key in a lock. Thereby promoting the death of cancer cells without harming the body’s healthy cells.
Like the old parable of the beggar who was sitting on a treasure chest but never bothered to look inside, governments and the medical establishment have been slow to realize the miraculous anti-cancer properties of marijuana. Finally, in this extraordinary documentary, the truth comes out.
A powerful and eye-opening film about the future of cannabis—and perhaps even the future of medicine. Written and directed by BBC filmmaker Len Richmond. Narrated by Emmy-winning actor Peter Coyote. Featuring interviews with…
* Dr. Robert Melamede, Associate Professor and Biology Chairman, University
* Dr. Sean D. McAllister, PhD, researcher at the California Pacific Medical
Center, San Francisco.
* Dr. Jeffrey Hergenrather, M.D.
* Dr. David Bearman M.D.
* Dr. Manuel Guzman, Ph.D. Professor of Biochemistry and Molecular Biology, School of Biology Complutense University Madrid, Spain
* Dr. Raphael Mechoulam, Professor of Medical Chemistry at the University of Jerusalem