Every human being on every developed nation on Earth, whether living in a rural or isolated area, in the middle of a large city, or near an industrialized area, now contains at least 700 contaminants in their body including pesticides, pthalates, benzenes, parabens, xylenes and many other carcinogenic and endrocrine disrupting chemicals.
We are being bombarded on a daily basis by an astronomical level of toxicity, all controlled by chemical terrorists on behalf of the food industry. Morever, many of these toxins affect our fertility and those of successive generations.
It’s time for people to know exactly what they are putting in their bodies and technology is coming to the rescue. University of Illinois at Urbana-Champaign researchers have developed a cradle and app that uses a phone’s built-in camera and processing power as a biosensor to detect toxins, proteins, bacteria, viruses and other molecules.
“We’re interested in biodetection that needs to be performed outside of the laboratory,” said team leader Brian Cunningham, a professor of electrical and computer engineering and of bioengineering at Illinois. “Smartphones are making a big impact on our society — the way we get our information, the way we communicate. And they have really powerful computing capability and imaging. A lot of medical conditions might be monitored very inexpensively and non-invasively using mobile platforms like phones. They can detect molecular things, like pathogens, disease biomarkers or DNA, things that are currently only done in big diagnostic labs with lots of expense and large volumes of blood.”
“Modern biological research is also allowing an extension of laboratory devices on to small computer chips to detect biological information within DNA sequences,” said biotech specialist Dr. Marek Banaszewski. “Bioinformatic algorithms within programs will aid the identification of transgenes, promoters, and other functional elements of DNA making detection of genetically modified foods on-the-spot and real-time without transportation to a laboratory.”
The wedge-shaped cradle created by Cunningham’s team contains a series of optical components — lenses and filters — found in much larger and more expensive laboratory devices. The cradle holds the phone’s camera in alignment with the optical components.
A D V E R T I S E M E N T
At the heart of the biosensor is a photonic crystal. A photonic crystal is like a mirror that only reflects one wavelength of light while the rest of the spectrum passes through. When anything biological attaches to the photonic crystal — such as protein, cells, pathogens or DNA — the reflected color will shift from a shorter wavelength to a longer wavelength.
The entire test takes only a few minutes; the app walks the user through the process step by step. Although the cradle holds only about $200 of optical components, it performs as accurately as a large $50,000 spectrophotometer in the laboratory. So now, the device is not only portable, but also affordable for fieldwork in developing nations.
In a paper published in the journal Lab on a Chip, the team demonstrated sensing of an immune system protein, but the slide could be primed for any type of biological molecule or cell type. The researchers are working to improve the manufacturing process for the iPhone cradle and are working on a cradle for Android phones as well. They hope to begin making the cradles available next year.
In addition, Cunningham’s team is working on biosensing tests that could be performed in the field to detect toxins in harvested corn and soybeans, and to detect pathogens in food and water.
Researchers at the Fraunhofer Research Institution for Modular Solid State Technologies EMFT in Regensburg have also engineered an ingenius solution to detecting toxins – a glove that recognizes if toxic substances are present in the surrounding air.
The protective glove is equipped with custom-made sensor materials and indicates the presence of toxic substances by changing colors. In this regard, the scientists adapted the materials to the corresponding analytes, and thus, the application. The color change — from colorless (no toxic substance) to blue (toxic substance detected). The researchers also envision other potential applications for the glove in the food industry.
Other handheld devices currently in development are portable chemiluminescence detectors, but based on enzyme-catalyzed reactions emitting light. The detection devices for nucleic acids, biotin associated with the target DNA provides the handle for the chemiluminescent detection. The non-radioactive DNA detection chemistry will be able to readily identify single-copy genes in transgenic plants making them suitable for GMO detection.
Marco Torres is a research specialist, writer and consumer advocate for healthy lifestyles. He holds degrees in Public Health and Environmental Science and is a professional speaker on topics such as disease prevention, environmental toxins and health p
A family of chemicals naturally produced by fungi are phenomenally effective at killing human cancer cells, according to a study conducted by researchers from the Massachusetts Institute of Technology, the University of Illinois at Urbana-Champaign and published in the journal Chemical Science.
“What was particularly exciting to us was to see, across various cancer cell lines, that some of them are quite potent,” lead researcher Mohammad Movassaghi said.
The study was funded by the National Institute of General Medical Sciences.
Researchers have known for some time that a fungal chemical known as 11,11′-dideoxyverticillin demonstrates cancer fighting properties, but the chemical occurs in such small quantities that it was impossible to test its potency. Then a few years ago, MIT scientists successfully synthesized the chemical in the lab.
11,11′-dideoxyverticillin is just one of a family a fungal chemicals known as epipolythiodiketopiperazine (ETP) alkaloids. Scientists believe that fungi use ETP alkaloids to prevent other organisms from moving into the territory where they are living. In the new study, the researchers artificially synthesized 60 different ETP alkaloids and related chemicals in order to test them against different cancer lines.
“There’s a lot of data out there, very exciting data, but one thing we were interested in doing is taking a large panel of these compounds, and for the first time, evaluating them in a uniform manner,” Movassaghi said.
Alkaloids target cancer cells, ignore healthy ones
The researchers tested each of the 60 compounds against both lymphoma and cervical cancer, then took the 25 most effective chemicals and further tested them against breast, kidney and lung cancers. They found that the cancer-fighting chemicals were 1,000 times more likely to kill a cancer cell than they were to kill a healthy cell.
Because the scientists had manufactured all 60 chemicals by systematically varying specific parts of their underlying chemical structure, they were then able to isolate the chemical properties that make these fungal compounds most effective against cancer.
For example, the researchers found that two ETP molecules joined together were more effective than solitary ETP molecules, and that compounds containing two sulfur atoms were more effective than those containing fewer.
Significantly, the researchers were also able to identify portions of the fungal molecules that can be changed without producing any reduction in cancer-fighting effectiveness. This may help scientists turn the naturally occurring ETPs into more potent anti-cancer drugs, by replacing these “neutral” sections of the molecule with antibodies or other molecules designed to specifically deliver the ETP to a cancer cell.
The researchers now plan to use their findings to develop more precise cancer-fighting ETPs.
“We can go in with far greater precision and test the hypotheses we’re developing in terms of what portions of the molecules are most significant at retaining or enhancing biological activity,” Movassaghi said.
Numerous drugs currently on the market have been derived from fungi. The most famous of these is penicillin, the first modern antibiotic, which was derived in 1929 from a species of mold known as Penicillium rubens.